Mitochondrial dynamics and disease, OPA1
نویسندگان
چکیده
منابع مشابه
Mitochondrial Function: OMA1 and OPA1, the Grandmasters of Mitochondrial Health
McVean, G.A., Gabriel, S.B., Reich, D., Donnelly, P., et al. (2005). Comparison of fine-scale recombination rates in humans and chimpanzees. Science 308, 107–111. 14. Ptak, S.E., Hinds, D.A., Koehler, K., Nickel, B., Patil, N., Ballinger, D.G., Przeworski, M., Frazer, K.A., and Paabo, S. (2005). Fine-scale recombination patterns differ between chimpanzees and humans. Nat. Genet. 37, 429–434. 15...
متن کاملMitochondrial OPA1, apoptosis, and heart failure.
AIMS Mitochondrial fusion and fission are essential processes for preservation of normal mitochondrial function. We hypothesized that fusion proteins would be decreased in heart failure (HF), as the mitochondria in HF have been reported to be small and dysfunctional. METHODS AND RESULTS Expression of optic atrophy 1 (OPA1), a mitochondrial fusion protein, was decreased in both human and rat H...
متن کاملMitochondrial dynamics in disease.
1707 M are subcellular organelles that coordinate numerous metabolic reactions, including those of the respiratory complexes that produce the ATP that powers cellular reactions. They have often been depicted as static, with a kidneybean shape, but there is a growing appreciation of their dynamic nature.1,2 Moreover, they are strikingly varied in structure, ranging from small, spherical particle...
متن کاملSIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress.
Mitochondrial morphology is regulated by the balance between two counteracting mitochondrial processes of fusion and fission. There is significant evidence suggesting a stringent association between morphology and bioenergetics of mitochondria. Morphological alterations in mitochondria are linked to several pathological disorders, including cardiovascular diseases. The consequences of stress-in...
متن کاملStress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.
The dynamic network of mitochondria fragments under stress allowing the segregation of damaged mitochondria and, in case of persistent damage, their selective removal by mitophagy. Mitochondrial fragmentation upon depolarisation of mitochondria is brought about by the degradation of central components of the mitochondrial fusion machinery. The OMA1 peptidase mediates the degradation of long iso...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2006
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2006.04.003